Here, we expand the repertoire of PROTAC compatible E3 ligases by identifying a novel small molecule scaffold targeting the ubiquitin E3 ligase KLHDC2 using a fluorescence polarization-based high ...

Resolution of OligoPrep (left) versus standard agarose (right). OligoPrep TM Synthetic Meltable Gel Matrix From National Diagnostics Imagine that purification of DNA or protein fragments was ...

After surrounding the brains (E17) with 4.5% UltraPure Low Melting Point Agarose (Invitrogen ... Original C6 cell lysate and immunoprecipitated proteins were resolved by SDS-PAGE (4- 20% Mini-PROTEAN ...

Large paralogous protein families are found throughout biology, the product of extensive gene duplication. To execute different functions inside cells, paralogs often acquire different specificities, ...

We use molecular, cellular and in vivo methods to study protein aggregation and defense mechanisms against it. Our work has unraveled molecular basis for aggregation of lung surfactant proteins, ...