Nature5d
Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule
Apoptosis is dependent on caspase activation, whereas the caspase-independent necrotic signaling pathway remains ... Jurkat T cells, the kinase receptor-interacting protein (RIP) was identified ...
News-Medical.Net5d
How olive oil bioactives regulate genes linked to insulin resistance
Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...
eLife6d
Scrutinized lipid utilization disrupts Amphotericin-B responsiveness in clinical isolates of Leishmania donovani
The management of Leishmania donova ni (LD), responsible for fatal visceral leishmaniasis (VL), faces increasing challenges due to rising drug-unresponsiveness, leading to increasing treatment ...
Physician's Weekly8d
Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax.
Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...
EurekAlert!13d
Schematic illustration of Z526's effects on cancer-associated cachexia. (IMAGE)
In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...
West Ham United F.C.21d
Academy trio inspire the next generation at Player Pathway session
Participants from the West Ham United Foundation’s Player Pathway programme were recently surprised by a visit from Academy players Ollie Scarles, Kaelan Casey and Fin Herrick. Boys from the U12s, ...
C&EN22d
Multifunctions of Sustainable Chondroitin Sulfates with Predominant Subtypes and Low Molecular Weights on Neurite Outgrowth
School of Life Science and Health Engineering, Jiangnan University, Wuxi 214122, China Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi ...
The EMBO Journal26d
A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease
AT2 dysfunction underlies many lung diseases, including interstitial lung disease (ILD), in which some inherited forms result from the mislocalization of surfactant protein C (SFTPC) variants. Lung ...
Health Affairs27d
Quality Pathway Implementation At The CMS Innovation Center
Last year, the CMS Innovation Center launched the Quality Pathway strategic initiative to strengthen the focus on quality in alternative payment models. Since it was created, the CMS Innovation ...
New York Post27d
The 16 best nutritionist-backed protein bars we tested for every diet
But FULFIL bars aren’t just stacked with 15 grams of protein, they’re also packed with vitamins A, B6, B12, C, and E to give you all the energy you need to get swinging. NY Post review ...
Ars Technica27d
Researchers use AI to design proteins that block snake venom toxins
It has been a few years since AI began successfully tackling the challenge of predicting the three-dimensional structure of proteins, complex molecules that are essential for all life. Next ...