The scientific design of a randomized controlled trial is as follows: Randomized: The researchers decide randomly as to which participants in the trial receive the new treatment and which receive ...

Randomized control trials are the most rigorous way of determining whether a cause-effect relationship exists between treatment and outcome and assessing a treatment’s cost-effectiveness.

The number of randomized trials assessing noninferiority increased by a factor of 6 in a decade — in 2005, just under 100 trials were listed in MEDLINE under the general rubric of ...

The well-recognized limitations of traditional randomized, controlled trials (RCTs), including their cost, the nature of the patients and providers included in them, and even the types of ...

Herson and Carter 19 proposed including a simultaneously randomized standard-treatment control arm in their trial. The EORTC has advocated use of this design and applied it in selected phase II trials ...

Both randomized controlled trials and real-world evidence can help define a treatment’s absolute value and its value relative to alternative interventions, but they do so in different ways.

Background: The addition of hyperthermic intraperitoneal chemotherapy (HIPEC) during interval cytoreductive surgery increases progression-free and overall survival for patients with stage III ovarian ...

Phase 3 randomized control trials, in which a group of people receive an experimental drug and are compared with another group receiving a placebo, are considered the gold standard for clinical ...

Clinical trials are carried out to ensure that medical practices and treatments are safe and effective. People with a health condition may choose to join in, as the trial may provide a new cure.