News

Satri-cel study marks first randomized CAR T-cell success in solid tumors
Satri-cel, a CLDN18.2-targeted CAR T-cell therapy, nearly doubles progression-free survival in patients with previously ...
Expanding The Role Of External Control Arms In Clinical Research
When executed with precision and transparency, ECAs can enhance trial efficiency, expand access and support evidence—while ...
ascopubs.org3d
Consistency of Phase III Clinical Trial Abstracts Presented at an Annual Meeting of the American Society of Clinical Oncology Compared With Their Subsequent Full-Text Publications
ASCO Annual Meeting abstracts of phase III trials consistently reflect final published results, but some differences were observed that warrant caution in using abstract results to shape treatment ...
Thorax7d
Randomised, placebo-controlled trial of oral hymecromone in adults with pulmonary hypertension
Background Pulmonary hypertension (PH) is a progressive cardiopulmonary condition associated with increased morbidity and ...
BMJ9d
Protocol for a multicentre randomised controlled trial to investigate the effect on asthma-related quality of life from breathing retraining in patients with incomplete asthma ...
Introduction and aim Uncontrolled asthma is a global health challenge with substantial impact on quality of life (QoL) and overall healthcare costs. Unrecognised and/or unmanaged comorbidities often ...
Health Affairs9d
Despite The FDA’s Five-Year Plan, Black Patients Remain Inadequately Represented In Clinical Trials For Drugs
Representativeness Of Pivotal Clinical Trials Disease burden information was available for 225 (232 drug-indication combinations) of the 290 drugs (appendix exhibit A3). 11 These 225 drugs ...
ahajournals.org12d
Sodium-Glucose Cotransporter 2 Inhibitors and Risk of Hyperkalemia in People With Type 2 Diabetes: A Meta-Analysis of Individual Participant Data From Randomized, Controlled Trials
Therefore, a meta-analysis was conducted of randomized, double-blind, placebo-controlled, clinical outcome trials with SGLT2 inhibitors in people with type 2 diabetes at high cardiovascular risk or ...
BMJ12d
Long-term maintenance of mycophenolate mofetil in anti-NMDA receptor encephalitis (LEARN): a multicentre, open-label, blinded-endpoint, randomised controlled trial
Despite its potential efficacy in refractory cases, including those with neuronal surface antigen-mediated encephalitis,14–16 there is a lack of definitive randomised controlled trials assessing ...
BMJ17d
Improving sleep and learning in rehabilitation after stroke, part 2 (INSPIRES2): study protocol for a home-based randomised control trial of digital cognitive behavioural ...
Therefore, the aim of this trial is to evaluate the potential for sleep improvement using a dCBT programme, to improve rehabilitation outcomes after stroke. Methods and analysis We will conduct a ...
UroToday18d
AUA 2025: Metastatic Hormone Sensitive Prostate Cancer – So Many Randomized Trials (Nine), yet Monotherapy Treatment Persists
8,9 PEACE-1 is a randomized phase III trial that employed a 2x2 design to assess, separately and combined, the impact of the addition of abiraterone acetate/prednisone and radiation to standard of ...
Frontiers19d
Comparative efficacy of dietary interventions for glycemic control and pregnancy outcomes in gestational diabetes: a network meta-analysis of randomized controlled trials
Methods: A systematic review and network meta-analysis of randomized controlled trials (RCTs) were conducted in accordance with PRISMA guidelines. Data were sourced from PubMed, MEDLINE, Embase, Web ...
BMJ20d
Effect of intravenous iron therapy on exercise performance, fatigue scores and mood states in iron-deficient recreationally active females of reproductive age: a double-blind ...
Methods Twenty-six recreationally active IDNA females were randomised to either an intravenous iron treatment ... Mood states and quality of life remained unchanged in both groups over the trial.