Liquid-like condensates as replication factories have been extensively studied in other viruses, including the rabies and measles viruses. In this study, the researchers investigated whether ...

With only seven genes, the BK polyomavirus must use the host cell's DNA replication machinery to produce new viruses. Although the virus was discovered over 50 years ago, little is known about how ...

Technical advances have made it possible to produce reassortant strains between wild-type viruses (for their antigenic properties) and culture-adapted strains (for their replication properties).

Bringing all the components to make viruses in one place makes replication more efficient and also helps hide the virus from the immune system. “Our current model is that ANKLE2 is really important, ...

Shah is senior author of the team’s published paper in mBio, titled “Microcephaly protein ANKLE2 promotes Zika virus replication.” In the paper, the team concluded that in combination with ...

Viral replication relies on the ability of viruses to exit host cells, a process known as viral egress, which is crucial for spreading infection to new ...

By dissecting the molecular interplay between the virus and its host, the researchers identified novel strategies that HIV-1 employs to ensure its replication while suppressing the host's cellular ...