For many eukaryotic introns, splicing is done in a series of reactions which are catalyzed by the spliceosome, a complex of small nuclear ribonucleoproteins (snRNPs) and associated proteins ...

Spliceosome structures have been investigated extensively in the past decade, but most of the studies have been restricted to a handful of model organisms. New research by Lu et al, looks outside this ...

This cover highlights the article Multimodal mechanisms of human centriole engagement and disengagement by Kei K. Ito, Shoji Hata, Daiju Kitagawa and colleagues. The cover image depicts the centriole ...

Get Instant Summarized Text (Gist) A new regulatory mechanism in RNA splicing has been identified, involving LUC7 proteins that influence spliceosome targeting of specific 5' splice sites. This ...

GENETIC researchers in Barcelona have reached a historic milestone, creating the very first map of the spliceosome. A key part of interpreting DNA, the spliceosome helps cells to interpret and ...

As the gene is copied, a machine called the spliceosome comes onto the RNA molecule to remove the introns and create the final RNA template used to produce proteins. The spliceosome works by ...

The spliceosome must identify the correct splice sites (SS) and branchsite (BS) used during splicing. E complex is the earliest spliceosome precursor in which the 5' SS and BS are defined. Definition ...