A genetic mutation that fuses two genes drives several different cancer types by forming networks of protein interactions that alter gene expression in cells, a study by UT Southwestern Medical Center ...

You may have seen it in the news recently: a baby in Pennsylvania with a rare genetic disorder was healed with a personalized treatment that repaired his specific genetic mutation.

The global Phenylketonuria (PKU) Treatment is undergoing a strategic transformation, driven by novel drug candidates and a more targeted understanding of unmet clinical needs. With a global prevalence ...

Researchers identified a novel genotype (D1.1) of highly pathogenic avian influenza H5N1 spreading among wild birds, poultry, ...

They used DNA sequencing technology to identify cellular mutations, or genetic changes that can help cancer form, grow, and spread. “Different carcinogens leave this characteristic pattern of ...

Broad Institute researchers have developed a way to edit the genetic sequences at the root of Huntington's disease and ...

The subject of the patent application was a recombinant Salmonella microorganism-based live vaccine designed to induce ...

However, it is unknown how patients specifically with sarcomere gene variants responded. Aims: To assess the effect of HCM-specific sarcomere gene variants on response to mavacamten. Methods: ...

This manuscript introduces a useful protein-stability-based fitness model for simulating protein evolution and unifying non-neutral models of molecular evolution with phylogenetic models. The model is ...

Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

Researchers corrected a specific gene mutation in baby KJ Muldoon‘s liver cells that had caused a rare metabolic disease called severe carbamoyl phosphate synthetase 1 (CPS1) deficiency ...

Using CRISPR, the team was able to create a treatment tailored to the baby's specific genetic mutation. Doctors began the process by creating a streamlined approach to base-editing therapy ...