Buried in the DNA of the long extinct woolly mammoth is a compound that scientists hope will one day yield a lifesaving ...

Learn about the crucial role of magnesium in your body, potential side effects of overconsumption, and how to safely include ...

This Account highlights recent advances in the total synthesis and development of a range of peptide-based natural product antibiotics and details the medicinal chemistry approaches used to optimize ...

There are many threats to our health and wellbeing, but one of the most serious is antibiotic resistant bacteria. Humans have ...

The star of the story is saarvienin A, a brand-new glycopeptide antibiotic produced by an unusual strain of Amycolatopsis, a ...

Can algae-based polymers replace plastic? Discover how renewable, biodegradable materials from algae are reshaping ...

Time-lapse analyses of millions of antibiotic-stressed Escherichia coli characterize the diverse single-cell dynamics of persister cells that depend on antibiotics, culture conditions, and ...

The authors confirm that telomeres in telomerase-positive cells terminate with 5'-ATC in a Pot1-dependent manner, and demonstrate that this principle holds true in telomerase-negative ALT cells as ...

In 1957, these MIT researchers finally achieved total synthesis of natural penicillin. Penicillin biosynthesis is often divided into three important steps. The first catalytic step is mediated by ...

Antibiotics historically developed to inhibit bacterial protein synthesis cross-react with mitochondrial ribosomes due to shared evolutionary features, impairing translation of key phosphorylation ...

Application: β-lactam antibiotics incorporate a nitrogen-containing β-lactam ring that plays a vital role in combating bacterial cell wall synthesis. Penicillin, for example, binds to bacterial cell ...

Antibiotics are medicines that are used to treat certain ... Cephalosporins work by interfering with cell wall synthesis to disrupt certain enzymes and treat bacterial infections like meningitis.