In a recent study published in the journal Proceedings of the National Academy of Sciences, researchers demonstrated that human transferrin ... endocytosis. Notably, treatment with the anti-TfR ...

The main intracellular route for iron uptake in cardiomyocytes is clathrin-mediated endocytosis ... However, higher concentrations of TFR antibody increased the blockage of the transferrin receptor, ...

To test their tetravalent TREM2 antibody in vivo, the researchers first increased its ability to enter the brain by attaching it to an antibody targeting the mouse transferrin receptor ... As for ...

Pabinafusp alfa is a recombinant fusion protein of an antibody against the human transferrin receptor and idursulfase, the enzyme that is missing or malfunctioning in people with Hunter syndrome. It ...

The transferrin ... antibody-mediated therapy. The TfR1 can be targeted by antibodies for cancer therapy in two distinct ways: (1) indirectly through the use of antibodies conjugated to anti-cancer ...

Low-density lipoprotein receptor (LDLR) in hepatocytes plays a key role in plasma clearance of circulating LDL and in whole body cholesterol homeostasis. The trafficking of LDLR is highly regulated in ...

The methods used to directly quantify antibody internalization are currently painstaking, time-consuming and not suitable for testing several antibodies at once. These assays usually require ...

After binding of its ligand transferrin, the transferrin receptor (TfR ... of non-permeabilized cells using a TfR-specific antibody that binds to the extracellular domain (Figure 5B). The recycling ...

thus also permitting evaluation of very low levels of receptor occupancy, even in cells with high levels of receptors. We added a comparative discussion of an antibody-uptake endocytosis assay and FAP ...

The dynamin dependence of fast endocytosis was also confirmed by FM1‐43 uptake assays. Ten‐minute pre‐incubation ... 2 (VAMP2), and the recycling endosome marker transferrin receptor, but rarely with ...

Now, Watts and colleagues demonstrate that bispecific antibodies that target both BACE and the transferrin receptor ... to cross the BBB via receptor-mediated endocytosis. In principle, the ...