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New Approach Expands Developmental Potential of Human Pluripotent Stem Cells
Conventional human pluripotent stem cells at the primed pluripotent state are capable of generating all the embryonic ...
EurekAlert!5d
A chemical approach to expand the developmental potentials of conventional human pluripotent stem cells
Extraembryonic trophoblast lineages constitute the placenta, and are essential for individual development. In human early embryo development, these cells can be generated from totipotent blastomeres.
Frontiers1y
Application of a JEG-3 organoid model to study HLA-G function in the trophoblast
The human placenta is a unique temporary organ with a mysterious immune tolerance. The formation of trophoblast organoids has advanced the study of placental development. HLA-G is uniquely expressed ...
Frontiers2y
Fluidic Flow Enhances the Differentiation of Placental Trophoblast-Like 3D Tissue from hiPSCs in a Perfused Macrofluidic Device
In this work, we created an in vitro placental trophoblast-like model via self-organization of human induced pluripotent stem cells (hiPSCs) in a perfused 3D culture macrofluidic device. This device ...