The sequence context of UBDs and the conformational ... are modified following various cellular stimuli) to effector proteins (ubiquitin receptors containing one or more UBDs) have been elucidated ...

is different from those of ubiquitin-like molecules, such as neuronal precursor cell expressed developmentally downregulated protein 8 (NEDD8), in which the C-terminal sequence is Leu-Ala-Leu-Arg ...

C-terminal amidation is a PTM that involves the addition of an amid group to the C-terminus of a peptide or protein. Currently there is no direct evidence to suggest that C-terminal amidation of ...

Based on their functional domains and ubiquitin transfer mechanisms, these poxvirus-encoded E3 ubiquitin ligases and adaptor proteins can be divided into ... the C-terminal 13 amino acid F-box-like ...

Vitamin E succinate has been found to inhibit tumor growth and enhance the effectiveness of immunotherapy by targeting ...

High levels of fat mass and obesity-associated protein (FTO) have been linked to increased tumor growth and resistance to ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality.

(F) Sequence alignment of U-box domains in ... His-TEV-HsUbcH5a, His-TEV- (Tetra-ubiquitin) and His-Strep-TEV-HsUbiquitin the cell lysates over expressing the proteins were prepared as above. After ...