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Findings uncover new mechanism linking cohesin complex to gene regulation
Cohesin is a protein that forms a ring-shaped complex which wraps and alters the DNA molecule shape. It moves through the DNA ...
Science News1d
Males of this ancient human cousin weren’t always bigger than females
Molecular evidence from a 2-million-year-old southern African hominid species indicates sex and genetic differences in P. robustus.
AlphaGalileo1d
Findings on the protein that forms loops in the human genome
Cohesin is a protein that forms a ring-shaped complex which wraps and alters the DNA molecule shape. It moves through the DNA ...
Myosin makes the moves to keep cell processes humming along
Biomolecular condensates are distinct molecular communities made of DNA, RNA and proteins that "condense" molecules to key ...
C&EN7d
Sequence-Specific Mapping of the Interaction between Urea and Unfolded Ubiquitin from Ensemble Analysis of NMR and Small Angle Scattering Data
In this study we have used extensive experimental NMR data, in combination with statistical coil ensemble modeling and small-angle scattering, to analyze the conformational behavior of the protein ...
eLife3mon
Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling
(A) Schematic representation of Homo sapiens (Hs) IFT172 protein domain organization ... leads to the loss of its ubiquitin ligase activity are represented as sticks (also highlighted in boxes within ...
eLife3mon
Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling
(F) Sequence alignment of U-box domains in ... His-TEV-HsUbcH5a, His-TEV- (Tetra-ubiquitin) and His-Strep-TEV-HsUbiquitin the cell lysates over expressing the proteins were prepared as above. After ...
AlphaGalileo4mon
Advancements in the research of the structure, function, and disease-related roles of ARMC5
ARMC5, a cytoplasmic protein encoded by a gene rich in armadillo (ARM) repeat sequences, has emerged as a critical regulator ...
Live Science7mon
2024 Nobel Prize in chemistry awarded to scientists who revealed a 'completely new world of protein structures'
Protein molecules are formed from many individual units called amino acids, which are encoded by three "letter" DNA sequences. It should therefore be possible to predict the 3D structure of a ...
The EMBO Journal1y
Systematic identification of 20S proteasome substrates
Alternatively, ubiquitin and ATP-dependent degradation of ... not only with that expected from the PiP-MS data but also with the protein’s intrinsic disorder prediction along its sequence. This ...
IEEE1y
Deep-USIpred: identifying substrates of ubiquitin protein ligases E3 and deubiquitinases with pretrained protein embedding and bayesian neural network
Abstract: Identifying the substrates of ubiquitin protein ligase (E3 ... which predicts E3/DUB-substrate interactions using protein sequences. The proposed Deep-USIpred model encodes protein sequences ...
The EMBO Journal1y
Cryo‐EM structure of the chain‐elongating E3 ubiquitin ligase UBR5
Sequence comparison of UBR boxes across ... and stain‐free imaging to visualise all proteins. Gels were subsequently stained using Coomassie staining to visualise ubiquitin levels. Gels of assays are ...