Autophagy is essentially the "rubbish collection" of our cells. If there are problems in this process, which is so important ...

Endocrine disruption during pregnancy and genetic drivers of bone disease were among the topics experts from UC San Francisco presented at the annual meeting of the Endocrine Society — ENDO 2025 — in ...

Democratic socialist Zohran Mamdani shocks the establishment by winning NYC's mayoral primary with progressive policies, endorsed by Sanders and AOC, signaling a leftward shift.

USP29 (ubiquitin‐specific protease 29) is a conventional deubiquitinase that belongs to the largest DUB subfamily. 13 Multiple biological functions and complex disease pathways have been found to be ...

Zhang X, Smits AH, Tilburg GBA, van, Jansen PWTC, Makowski MM, Ovaa H, and Vermeulen M An interaction landscape of ubiquitin signaling Mol Cell 2017 65 941-955.e8 ...

Structural Biology and Molecular Biophysics Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling ...

This important work advances our understanding of intraflagellar transport, ciliogenesis, and ciliary-based signaling, by identifying the interactions of IFT172 with IFT-A components, ...

This review explores the multifaceted functions of GSPT2, highlighting its involvement in cell cycle regulation and signaling pathways, as well as its potential as a tumor biomarker.

Cezanne-2 (Cez2) is a deubiquitinylating (DUB) enzyme involved in the regulation of ubiquitin-driven cellular signaling and selectively targets Lys11-linked polyubiquitin chains. As a representative ...

This complex balances adhesion and guidance signaling to regulate neuronal migration timing and direction. This "push" signal is balanced by a "pull" signal, driven by the ubiquitin ligase, Siah2.