Dogs that have oral squamous cell carcinomas often need surgery that disfigures their jaws and lower their quality of ...

This study presents a valuable nonlinear mathematical model that addresses how cell shape transitions in response to ECM stiffness. The evidence supporting the claims of the authors is solid, although ...

Learn about our Editorial Policies. “Focus has been on how cells become mechanosensitive, how cell adhesion became mechanosensitive through the recruitment of mechanosensitive proteins like talin, ...

Talin rod, vinculin, paxillin, and adaptor protein p130Cas dock to each other and transfer the mechanical cues from integrins to the actin component of the cytoskeleton. In close proximity with the FA ...

Integrins require an activation step prior to ligand binding and signaling. How talin and kindlin contribute to these events in non-hematopoietic cells is poorly understood. Here we report that ...