This relatively simple, primordial acetyl-CoA metabolic pathway has survived in many microorganisms to this day. To discover more about the metabolism of what were probably among the very first ...

This perspective is being reshaped by emerging research that highlights the contribution of metabolic pathways to OA development and progression. New research recently published in the journal ...

The MC4R pathway regulates hunger and energy expenditure. Cancer patients can develop obesity after surgery or radiation to treat brain tumors. These treatments can damage the hypothalamus ...

1 Guangdong Key Laboratory of Fermentation and Enzyme Engineering, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China 2 Guangdong Research Center of ...

We discuss here the methodology for calculating STY using model organisms Pichia pastoris and Chinese hamster ovary cells (CHO), highlighting the unique attributes of fed-batch versus continuous ...

The approach is based on a hierarchical dynamic control system around the key pathway intermediate malonyl-CoA. The upper level of the control system ensures downregulation of endogenous use of ...

The two Prehistoric Rock Art Sites in the Côa Valley (Portugal) and Siega Verde (Spain) are located on the banks of the rivers Agueda and Côa, tributaries of the river Douro, documenting continuous ...

A study from Van Andel Institute reveals that immune cells use two pathways, ACLY and ACSS2, to produce acetyl-CoA, an essential metabolite for fighting infection and cancer. These findings highlight ...

Pichia pastoris possesses a highly efficient secretion pathway, effectively releasing recombinant proteins into the extracellular environment. This feature simplifies downstream processing and ...

Coverage from the panel discussion, "Can Clinical Pathways Have Burnout, Too?" at Patient-Centered Oncology Care 2023. While clinical pathways in oncology were initially integrated to guide ...

metabolism and increases the level of acetyl-CoA and malonyl-CoA, which are the major lipid components of the liver in NAFLD. Increased level of acetyl-CoA and malonyl-CoA lead to increased ...