Endocervical and Squamous Metaplastic Cells on a Pap Smear - Healthline
Apr 28, 2022 · Seeing squamous metaplastic or endocervical cells on your Pap smear test results may raise some questions and concerns. However, the presence of these cells isn’t usually a cause for concern.
p16INK4A (henceforth referred to as p16) immunohistochemistry (IHC) is a good surrogate test for the presence of a potentially transforming human papillomavirus (HPV) infection in anogenital carcinomas and premalignant lesions1. p16 is a 16 kDa protein encoded by CDKN2A, within the INK4/ARF tumour suppressor locus on Chromosome 9 (9p21.3)2,3.
Pathology Outlines - Squamous metaplasia
Oct 30, 2020 · Squamous metaplasia is a preferential site for high risk HPV infection and HPV related carcinogenesis and thus is a hot spot for developing squamous intraepithelial lesion (SIL) and squamous cell carcinoma.
Squamous Metaplasia: Causes, Symptoms and Treatments - Cleveland Clinic
Jun 15, 2022 · Changes to epithelial cells that line organs, glands and skin cause squamous metaplasia. It may be a noncancerous or precancerous condition. In women with HPV, squamous metaplasia raises the risk of cervical dysplasia and cervical cancer.
Interpretation of p16, p53 and mismatch repair protein ...
Patchy p16 staining may be seen in normal cervical squamous epithelium (a) and endocervical glandular epithelium (b). Immature squamous metaplasia of the cervix (c) typically shows patchy p16 staining with sparing of the basal layer (d).
Cervical Pre-cancers: Biopsy and Immunohistochemistry - PMC
p16 INK4a and Ki-67 immunohistochemistry assist in the histological differential diagnosis of precursor lesions and the reactive and metaplastic epithelium . Ki-67 indicates cellular multiplication and is a marker of cellular proliferation. Most …
CK17 and p16 expression patterns distinguish (atypical) immature ...
Apr 1, 2007 · Metaplastic epithelium was divided into mature and immature forms. The earliest phase of immature metaplasia was a proliferation of individual reserve cells. CK17 stained the cytoplasm (Figure 1a) and p63 the nuclei (Figure 1b).
P16/Ki-67 Immunostaining is Useful in Stratification of Atypical ...
This study aims to establish staining characteristics of metaplastic squamous epithelium and determine if p16/Ki-67 is useful in ASM stratification. 80 cervical biopsies containing morphologically normal and dysplastic squamous metaplasia were retrieved to determine the staining characteristics of metaplastic epithelium utilizing p16/Ki-67 immun...
Expression of P63, P16 and CK17 in Atypical Squamous Metaplasia …
The P16 was considered as positive when it showed nuclear and continuous cells diffuse cytoplasmic staining in the basal and para-basal squamous epithelium cell layers, which variably reached intermediate and superficial cell layer characteristic of a diffuse staining pattern.
p16 and Ki-67 Immunostaining in Atypical Immature Squamous …
Sep 1, 2007 · Results of that study confirmed that AIM represents a spectrum of lesions, from HPV-negative, benign, immature squamous metaplasia to hrHPV-positive cases representing either HSIL or an HSIL precursor.