Our data revealed that the signal sequences of tPA and IL-6-modified receptor binding domain (RBD) mRNA vaccines sequentially led to higher antigen expression and elicited more robust …

In vertebrates, the region of the mRNA that codes for the signal peptide (i.e. the signal sequence coding region, or SSCR) can function as an RNA element with specific activities. SSCRs …

May 28, 2024 · Our data revealed that the signal sequences of tPA and IL-6-modified receptor binding domain (RBD) mRNA vaccines sequentially led to higher antigen expression and …

Nov 2, 2023 · The spike (S) protein of SARS-CoV-2 is the main target of mRNA vaccine design, but the impact of the signal peptide (SP), transmembrane region (TM), and cytoplasmic tail …

SignalP gives a score for the predicted likelihood of the sequence containing a functional eukaryotic SRP pathway signal peptide (called the Sec/SPI score) between 0 and 1, with …

Aug 1, 2018 · A great majority of secretory proteins in all domains of life carry a short peptide at their N-terminals, called signal peptide (SP). SPs act as zip codes marking the protein …

Mar 23, 2022 · Among these, the COVID-19 messenger RNA (mRNA) vaccine has been drawing increasing attention owing to its great application prospects and advantages, which include …

Mar 20, 2024 · When the newly synthesized mRNA encodes a signal peptide, the mature mRNA is exported from the nucleus to the cytoplasm with its 5′-cap bound by the CBC and is subject …

Oct 9, 2023 · The spike (S) protein of SARS-CoV-2 is the main target of mRNA vaccine design, but the impact of the signal peptide (SP), transmembrane region (TM), and cytoplasmic tail …

signal peptides differed in their binding capacities with the signal recognition particle (SRP) 54 M subunit, which positively correlated with antigen translation efficiency. Our data revealed that …