In lymphatic malignancies serum B2M has significant prognostic value. Interferons (IFNs) have the ability to enhance the expression of class I and II histocompatibility antigens. Accordingly, …

β2M expresses at a constant level in many cells, however, the formation of β2M would be enhanced in the presence of IFN-α. β2M could induce the expression of interleukin 6 (IL-6), 8 …

Interferon-gamma (IFNG) augments immune function yet promotes T cell exhaustion through PDL1. How these opposing effects are integrated to impact immune checkpoint blockade …

Feb 18, 2019 · B2M −/− CIITA −/− hiPSCs resulted in an IFN-γ release reaching roughly one-third of the spot frequency of the highly NK cell susceptible K562 line, whereas B2M −/− CIITA −/− …

Taking into account the many recent advances in B2M-related melanoma immunity, here we discuss the immune function of the B2M gene in tumors, its common genetic alteration in …

Jan 19, 2023 · Here, we systematically investigate the genetic determinants of IFN-γ response in colorectal cancer cells using CRISPR-Cas9 screens and base editing mutagenesis.

Our study suggests that genetic and epigenetic regulation of B2M fundamentally shapes the immune landscape of lung adenocarcinomas (LUADs) and determines the response to …

May 4, 2018 · Thus, disruption of antigen presentation is a key mechanism of tumor immune evasion, demonstrated by loss-of-function mutations in the genes encoding β 2-microglobulin …

Oct 1, 2021 · B2M mutations have been identified in considerable cancer patients. Increasing evidence has indicated that B2M gene alterations in tumor cells may lower the efficacy of T …

Recurrent immunotherapy failure observed in patients with IFNγ pathway deficiencies. IFNγ signaling pathway and MHC class I regulation require profound molecular understanding to …