Feb 29, 2024 · Clozapine is available only from a certified pharmacy under a special program. Warnings. Clozapine affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, sore throat, weakness, or lack of energy. Clozapine can increase your risk of seizure, especially at high doses.

Jan 23, 2025 · Clozapine is almost completely metabolized prior to excretion, and only trace amounts of unchanged drug are detected in the urine and feces. Clozapine is a substrate for many cytochrome P450 isozymes, in particular CYP1A2, CYP2D6, and CYP3A4. Approximately 50% of the administered dose is excreted in the urine and 30% in the feces.

Nov 19, 2024 · Clozapine can cause severe neutropenia (ANC <500/mm 3), which may lead to serious and potentially fatal infections. Patients initiating or continuing treatment with clozapine must have a baseline blood ANC before initiating clozapine therapy and regular ANC monitoring during treatment. (See Severe Neutropenia under Cautions.)

Nov 19, 2024 · Use clozapine cautiously in patients with cardiovascular or cerebrovascular disease or conditions predisposing to hypotension (eg, dehydration, use of antihypertensive medications).Seizures. Seizures have occurred with clozapine treatment. The risk is dose-related. Initiate treatment at 12.5 mg, titrate gradually, and use divided dosing.

Jan 1, 2025 · Clozapine can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV. Using Clozaril with other drugs that make you drowsy or slow your breathing can cause dangerous side effects or death.

Dec 13, 2024 · Concomitant use of clozapine is not recommended, however, if a strong CYP450 3A4 inducer is necessary, a dose increase of clozapine dose may be needed. Monitor for decreased effectiveness. When discontinuing a strong CYP450 3A4 inducer and continuing clozapine: Reduce clozapine dose based on clinical response.

Clozapine Interactions There are 937 drugs known to interact with clozapine , along with 20 disease interactions, and 4 alcohol/food interactions. Of the total drug interactions, 480 are major, 450 are moderate, and 7 are minor.

Clozapine (International) In the US, Clozapine (clozapine systemic) is a member of the drug class atypical antipsychotics and is used to treat Borderline Personality Disorder, Paranoid Disorder and Schizophrenia.

Nov 25, 2024 · For abrupt clozapine discontinuation for a reason unrelated to neutropenia, continuation of the existing ANC monitoring is recommended for general population patients until their ANC is ≥1500/µL and for BEN patients until their ANC is ≥1000/µL or above their baseline.

Clozapine has an average rating of 7.8 out of 10 from a total of 77 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 17% reported a negative effect. View all 2160 reviews