Oct 19, 2020 · In this paper, we propose a novel codon optimization method based on deep learning. First, we introduce the concept of codon boxes, via which DNA sequences can be …

Feb 1, 2016 · Here we report a method to reduce the redundancy of codons by artificially dividing codon boxes to create vacant codons that can then be reassigned to non-proteinogenic amino …

Split codon boxes are those encoding two amino acids (or amino acid(s) plus stop codon; see Fig. 1). Un-split codon boxes encode a single amino acid (e.g., Pro, Ala, Gly).

Sep 9, 2016 · We derive a more information-rich, alternative representation of the genetic code, that is circular with an unsymmetrical distribution of codons leading to a clear segregation …

There have been three main approaches to alter or expand the genetic code in vitro (Fig. 1). Sense codon reprogramming allows for reassignment of a codon box to an ncAA (Fig. 1A). …

Here, we describe the protocol of a recently published method to artificially divide such family codon boxes and encode multiple nonproteinogenic amino acids in addition to the 20 …

In the genetic code table, each codon box contains codons that start with the same two bases but differ by the third base. Hence, each codon box harbors four codons. In split-codon boxes …

In this paper, we propose a novel codon optimization method based on deep learning. First, we introduce the concept of codon boxes, via which DNA sequences can be recoded into codon …

Feb 6, 2018 · Here, we describe the protocol of a recently published method to artificially divide such family codon boxes and encode multiple nonproteinogenic amino acids in addition to the …

ontains eight family codon boxes consisting of synonymous codons that redun-dantly code for the same amino acid. Here, we describe the protocol of a recently published method to artificially …