Non-hyperpolarizing GABAB receptor activation regulates ... - Nature
Apr 30, 2013 · Here we address GABA B R function during rat cortical development by in utero knockdown (short interfering RNA) of GABA B R in pyramidal-neuron progenitors. GABA B R …
- Author: Guillaume Bony, Joanna Szczurkowska, Ilaria Tamagno, Maya Shelly, Andrea Contestabile, Laura Cancedd...
- Publish Year: 2013
Diversity of structure and function of GABAB receptors: a …
GABAB receptors are G protein-coupled receptors that mediate slow and prolonged inhibitory action, via ... γ-aminobutyric acid type B (GABAB) receptors are broadly expressed in the …
Molecular mechanisms of metabotropic …
G αi inhibits adenylyl cyclase reducing the level of cyclic adenosine 3′,5′-monophosphate (cAMP) in the cell, while G βγ …
- Author: Hamidreza Shaye, Benjamin Stauch, Cornelius Gati, Cornelius Gati, Vadim Cherezov
- Publish Year: 2021
Regulation of neuronal GABAB receptor functions by subunit
May 18, 2012 · GABA B receptors (GABA B Rs) are the G protein-coupled receptors for the inhibitory neurotransmitter GABA. Activation of these receptors is involved in pre- and …
- Author: Martin Gassmann, Bernhard Bettler
- Publish Year: 2012
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Cyclic AMP–dependent protein kinase phosphorylation facilitates …
Mar 25, 2002 · GABA (Îł-aminobutyric acid) B receptors are heterodimeric G protein–coupled receptors that mediate slow synaptic inhibition in the central nervous system. Here we show …
- Author: Andrés Couve, Philip Thomas, Andrew R. Calver, Warren D. Hirst, Menelas N. Pangalos, Frank S. Walsh,...
- Publish Year: 2002
Upregulation of cAMP/PKA/CREB signaling mediated by GABA
Jan 1, 2025 · Research suggests that alterations in Îł-aminobutyric acid type B receptors (GABA B R) are associated with various cognitive function, including working, short-term, long-term, and …
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GABAB Receptors: Molecular Organization, Function, and
Sep 18, 2024 · GABA B receptors activate G i/o proteins. The activated Gα i/o subunit inhibits adenylate cyclases (not depicted), lowering cAMP levels, while the Gβγ dimer activates K + …
GABAB receptors and norepinephrine-stimulated cAMP …
Jul 23, 1984 · It was found that GABAB receptor agonists such as GABA, baclofen, and kojic amine potentiate the cAMP response in cerebral cortex during exposure to norepinephrine. …
Disappearance of gamma-aminobutyric acid (GABA)B receptor …
However, the suppressive effect of baclofen, a GABAB agonist, on forskolin-stimulated cAMP formation in cerebral cortical slices of these animals was abolished. These results indicate that …
Single-Molecule Fluorescence Imaging Reveals GABAB Receptor …
With the imaging of the GABAB receptor on the cell membrane by using a total internal reflection fluorescence microscope (TIRFM), we revealed the key sites on the hydrophobic interface for …
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