In organic chemistry, polyketides are a class of natural products derived from a precursor molecule consisting of a chain of alternating ketone (>C=O, or its reduced forms) and methylene (>CH2) groups: [−C (=O)−CH2−]n. [1] . First studied in the early 20th century, discovery, biosynthesis, and application of polyketides has evolved.

Polyketide synthases (PKSs) are a family of multi- domain enzymes or enzyme complexes that produce polyketides, a large class of secondary metabolites, in bacteria, fungi, plants, and a few animal lineages. The biosyntheses of polyketides share striking similarities with fatty acid biosynthesis. [1][2]

Mar 31, 2020 · ketide (plural ketides) (organic chemistry) Any organic compound containing adjacent methylene and carbonyl functional groups.

In organic chemistry terms the difference between ketone and ketide is that ketone is a homologous series of organic molecules whose functional group is an oxygen atom joined to a carbon atom—by a double bond—in a carbon-hydrogen based molecule while ketide is any organic compound containing adjacent methylene and carbonyl functional groups.

Polyketides are a diverse group of natural products derived from acetyl- or malonyl- units, with structural features such as polyphenols, macrolides, and polyenes. They are considered 'lipids' due to their solubility in organic solvents and have various applications including antimicrobial, antiparasitic, and anticancer uses.

Mar 16, 2021 · The polyketides, a diverse family of highly oxygenated natural products, are characterized by the presence of many β-dihydroxy or β-hydroxycarbonyl consonant polar functional relationships. Some polyketides have carbon skeletons comprized of a long straight chain of carbon atoms that is often crosslinked into one or more six-membered rings.

Polyketide synthases (PKSs) are structurally and functionally related to fatty acid synthases (FAS’s), as both enzyme classes catalyzes the condensation of activated primary metabolites (acetyl-CoA and malonyl-CoA) to form b -ketoacetyl polymers linked to …

Definition of ketide in the Definitions.net dictionary. Meaning of ketide. What does ketide mean? Information and translations of ketide in the most comprehensive dictionary definitions resource on the web.

Polyketide retrobiosynthesis, where the biosynthetic pathway of a given polyketide can be reversibly engineered due to the colinearity of the polyketide synthase (PKS) structure and function, has the potential to produce millions of organic molecules.

Polyketides are a large class of important secondary metabolites produced by bacteria, fungi, plants and animals (Staunton & Weissman, 2001).