In this regard, we set out to collect up-to-date information on the HepG2 cell line to assess whether the level of heterogeneity of the cell line allows in vitro biomedical studies as a model with guaranteed production and quality. Keywords: HepG2 cell line, mutations, hepatocellular carcinoma, hepatoblastoma, hepatocytes. 1. Introduction.

Hep G2 [HEPG2] is a cell line exhibiting epithelial-like morphology that was isolated from a hepatocellular carcinoma of a 15-year-old, White, male youth with liver cancer. The cell line was deposited by the Wistar Institute and is a suitable transfection host.

Our results suggest that galactose reduces both glycolytic and biosynthetic flux and restores a metabolic poise in HepG2 cells that closely reflects the metabolic state observed in primary hepatocytes. Keywords: galactose, HepG2, mitochondria, NAD, redox state.

HepG2 cells, originating from human hepatoma, have become an invaluable tool for researching liver functions and diseases, including hepatocellular carcinoma. These hepatic cell lines provide insights into the cellular responses of human hepatocytes under various experimental conditions.

Jun 1, 2015 · HepG2 cells are a better model than fresh human hepatocytes to define mito-toxicity. Drug-induced mitochondrial dysfunction has been hypothesized to be an important determining factor in the onset of drug-induced liver injury.

HepG2 cells are nontumorigenic cells with high proliferation rates and an epithelial-like morphology that perform many differentiated hepatic functions. In this chapter, freezing, thawing, and subculturing procedures for HepG2 cells are described.

To represent the composition of small molecules circulating in HepG2 cells and the formation of the “core” of characteristic metabolites that often attract researchers’ attention, we conducted a meta-analysis of 56 datasets obtained through metabolomic profiling …

May 17, 2010 · Apolipoprotein B (apoB) containing lipoproteins, i.e. VLDL, LDL and Lp (a), are consequently lowered by ACTH treatment in humans. This is also seen as reduced plasma apoB by 20-30% and total cholesterol by 30-40%, mostly …

Oct 10, 2024 · Hep G2 cells play a pivotal role in studying liver cancer development, drug metabolism, and toxicity, making them an essential tool for research into liver-related diseases and therapies. Cell Names:Hep G2 Cell Line Human (HepG2, HEPG2) (ATCC HB-8065); a.k.a. Human hepatoma-derived cell line, hepatocellular carcinoma, hepatoblastoma cell line.

Hep G2 (or HepG2) is a human liver cancer cell line. Hep G2 is an immortal cell line which was derived in 1975 from the liver tissue of a 15-year-old Caucasian male from Argentina with a well-differentiated hepatocellular carcinoma. [1] .