Seryl-tRNA synthetase specificity for tRNASec in Bacterial Sec ...
Here we describe the molecular interactions between the Escherichia coli Seryl-tRNA synthetase (EcSerRS) and tRNA [Ser]Sec in order to determine their specificity, selectivity and binding …
Seryl tRNA synthetase cooperates with POT1 to regulate ... - Nature
Nov 29, 2019 · Here, we explored the possible roles of aminoacyl tRNA synthetases (AARSs), key enzymes catalyzing the first reactions in protein synthesis, in regulating telomere length …
Designing seryl-tRNA synthetase for improved serylation of ...
Guided by structural modeling and selection for chloramphenicol acetyltransferase activity, we evolved three SerRS variants capable of improved Ser-tRNA Sec synthesis. They display 10-, …
Protein–Protein Interactions of Seryl-tRNA Synthetases with …
Seryl-tRNA synthetases (SerRSs), members of the aminoacyl-tRNA synthetase family, interact with diverse proteins, enabling SerRSs to enhance their role in the translation of the genetic …
Seryl-tRNA synthetase from Escherichia coli: implication of its N ...
Escherichia coli seryl-tRNA synthetase (SerRS) a dimeric class II aminoacyl-tRNA synthetase with two structural domains charges specifically the five iso-acceptor tRNA (ser) as well as the …
The tRNA methyltransferase METTL6 requires seryl-tRNA
Jun 25, 2024 · Overexpression of the RNA methyltransferase METTL6 leads to increased proliferation and promotes cancer. Our cryo-electron microscopy (cryo-EM) and biochemical …
Seryl-tRNA synthetase from Escherichia coli: functional evidence …
Apr 4, 1995 · Escherichia coli seryl-tRNA synthetase (SerRS) is a homo-dimeric class II aminoacyl-tRNA synthetase. Each subunit is composed of two distinct domains: the N-terminal …
Insights into substrate promiscuity of human seryl-tRNA …
Seryl-tRNA synthetase (SerRS) attaches L-serine to the cognate serine tRNA (tRNA Ser) and the noncognate selenocysteine tRNA (tRNA Sec). The latter activity initiates the anabolic cycle of …
Seryl-tRNA synthetase promotes translational readthrough by …
Oct 27, 2023 · Seryl-tRNA synthetase (SerRS) charges tRNASec with serine, which is modified into selenocysteine and delivered to the ribosome by a designated elongation factor (eEFSec …
Exploration of seryl tRNA synthetase to identify potent inhibitors ...
May 15, 2023 · In the current study, seryl tRNA synthetase of Leishmania donovani (Ld SerRS) and its mutants were purified and characterized through biochemical and structural methods. …
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