Ubiquitin is a small (8.6 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e., it is found ubiquitously.It was discovered in 1975 [1] by Gideon Goldstein and further characterized throughout the late 1970s and 1980s. [2] Four genes in the human genome code for ubiquitin: UBB, UBC, UBA52 and RPS27A. [3]The addition of …

Mar 16, 2023 · Ubiquitination (also known as ubiquitylation) is a form of post-translation modification (PTM) in which ubiquitin is attached to a target protein. Ubiquitin is a 76 amino acid protein that exists in the free form or can be conjugated to a protein as a single ubiquitin (ie, monoubiquitination) or as a multiple ubiquitin (ie, polyubiquitination). Ubiquitination plays versatile roles in protein ...

Jan 14, 2021 · Ubiquitin modifications control a plethora of vital cellular processes through proteolytic and nonproteolytic mechanisms, including proteasomal degradation and proteostasis, selective autophagy ...

Ubiquitination is an enzymatic process characterized by the covalent attachment of ubiquitin to target proteins, thereby modulating their degradation, transportation, and signal transduction. By precisely regulating protein quality and quantity, ...

Aug 23, 2018 · Ubiquitin is a small protein that is found in almost all cellular tissues in humans and other eukaryotic organisms, which helps to regulate the processes of other proteins in the body.

Nov 29, 2004 · Ubiquitin is the founding member of a family of structurally conserved proteins that regulate a host of processes in eukaryotic cells. Ubiquitin and its relatives carry out their functions through covalent attachment to other cellular proteins, thereby changing the stability, localization, or activity of the target protein.

The protein ubiquitin is a covalent modifier of proteins, including itself. The ubiquitin system encompasses the enzymes required for catalysing attachment of ubiquitin to substrates as well as proteins that bind to ubiquitinated proteins leading ...

Jan 16, 2025 · The modification of proteins and other biomolecules with the small protein ubiquitin has enthralled scientists from many disciplines for decades, creating a broad research field. Ubiquitin research is particularly rich in molecular and mechanistic understanding due to a plethora of (poly)ubiquitin s …

Feb 28, 2024 · Ubiquitin is a small (8.6 kDa) protein that is found ‘ubiquitously’ in eukaryotic organisms and functions as a regulator of numerous cellular processes. It is a multifaceted post-translational modifier of other proteins involved in almost all eukaryotic biology. Once bound to a substrate, ubiquitin initiates a plethora of distinct signals with …

The 2004 Nobel Prize in chemistry for the discovery of protein ubiquitination has led to the recognition of cellular proteolysis as a central area of research in biology. Eukaryotic proteins targeted for degradation by this pathway are first 'tagged' by …