RNAs are a type of large biological molecules, whose individual building blocks are called nucleotides. The name poly(A) tail (for polyadenylic acid tail) reflects the way RNA nucleotides are abbreviated, with a … See more

There is polyadenylation in the cytosol of some animal cell types, namely in the germline, during early embryogenesis and in post- See more

For many non-coding RNAs, including tRNA, rRNA, snRNA, and snoRNA, polyadenylation is a way of marking the RNA for degradation, at least in yeast. This polyadenylation … See more

Although polyadenylation is seen in almost all organisms, it is not universal. However, the wide distribution of this modification and the fact that it is … See more

Function
In nuclear polyadenylation, a poly(A) tail is added to an RNA at the end of transcription. On mRNAs, the poly(A) tail protects the mRNA molecule from enzymatic degradation in the cytoplasm and aids in … See more

Many protein-coding genes have more than one polyadenylation site, so a gene can code for several mRNAs that differ in their See more

In many bacteria, both mRNAs and non-coding RNAs can be polyadenylated. This poly(A) tail promotes degradation by the degradosome, which contains two RNA-degrading enzymes: polynucleotide phosphorylase and RNase E. Polynucleotide … See more