Sep 1, 2012 · Mechanistically, ectopic expression of AMPK enhanced the acetylation and stability of p53 in HCC cells. The p53 deacetylase, SIRT1, was phosphorylated and inactivated by …

Apr 29, 2005 · Activation of AMPK leads to phosphorylation of p53 at serine 15 (serine 18 of mouse p53), and this phosphorylation event is essential for mediating the effects of AMPK on …

AMP-activated protein kinase (AMPK) has been shown to activate p53 in response to metabolic stress. However, the underlying mechanisms remain unclear. Here we show that metabolic …

Apr 29, 2005 · AMPK-induced p53 activation promotes cellular survival in response to glucose deprivation, and cells that have undergone a p53-dependent metabolic arrest can rapidly …

AMPK, by regulating a variety of downstream targets, such as mTORC1, p53 and fatty acid synthase (FASN), and associated metabolic processes, controls intracellular energy levels in …

In this study, we found that the AMPK/PGC-1α and p53 pathways mediate the upregulation of VDAC1, known as the mitochondrial gatekeeper, in metabolic oxidative stress. …

AMP-activated protein kinase (AMPK) has been shown to activate p53 in response to metabolic stress. However, the underlying mechanisms remain unclear. Here we show that metabolic …

Apr 15, 2013 · Here, we show that Myc-induced altered glutamine metabolism involves ATP depletion and activation of the energy sensor AMP-activated protein kinase (AMPK), which …

Aug 30, 2012 · Mechanistically, ectopic expression of AMPK enhanced the acetylation and stability of p53 in HCC cells. The p53 deacetylase, SIRT1, was phosphorylated and inactivated …

Feb 15, 2008 · In this study, we have found that glucose depletion promotes the phosphorylation of AMP-activated protein kinase catalytic subunit α (AMPKα) in association with a significant …