
Principles of start codon recognition in eukaryotic translation ...
Selection of the correct start codon during initiation of translation on the ribosome is a key event in protein synthesis. In eukaryotic initiation, several factors have to function in concert to ensure …
Interpreting cDNA sequences: some insights from studies on
This review discusses some rules for assessing the completeness of a cDNA sequence and identifying the start site for translation. Features commonly invoked-such as an ATG codon in …
Effect of ATG initiation codon context motifs on the efficiency of ...
Mar 10, 2014 · The context sequence motif surrounding the ATG initiation codon influences mRNA translation efficiency and affects protein production; however, the optimal sequence …
Sequence Architecture Downstream of the Initiator Codon …
We examined a dataset of highly expressed plant genes to see if they had features conserved downstream of the ATG initiator codon and if such features were in contrast to the genes …
Start codon disruption with CRISPR/Cas9 prevents murine Fuchs ...
Jun 8, 2021 · An adenine insertion produced a cryptic ATG codon that resulted in disruption of Kozak sequence (G to C at −3 position).
ORFfinder Home - NCBI
Use 'ATG' only as ORF start codon, or all alternative start codons, corresponding to the selected genetic code, or any sense codon (find all stop-to-stop ORFs)
New Universal Rules of Eukaryotic Translation Initiation Fidelity
The accepted model of eukaryotic translation initiation begins with the scanning of the transcript by the pre-initiation complex from the 5′end until an ATG codon with a specific nucleotide (nt) …
The Effect of an Alternate Start Codon on Heterologous ... - PubMed
May 26, 2015 · Analysis of the annotated genomes found that ATG was the most prevalent translational start codon among Mycoplasma spp. However in Mycoplasma gallisepticum a …
Fndc5 is translated from an upstream ATG start codon and
May 7, 2024 · Witmer et al. provide genomic and molecular evidence to demonstrate that Fndc5 (irisin myokine precursor protein) is translated in humans from an overlooked upstream ATG …
Repeat Associated Non-ATG translation: molecular mechanisms …
Driving higher levels of expression of specific RAN proteins in a particular reading frames with ATG-initiation codon has also been shown to increase cell death and decrease cell viability in …