2C-B (4-bromo-2,5-dimethoxyphenethylamine), also known as Nexus, is a synthetic psychedelic drug of the 2C family, mainly used as a recreational drug. [2] [1] [4] It was first synthesized by Alexander Shulgin in 1974 for use in psychotherapy.

The cannabinoid receptor 2 (CB2), is a G protein-coupled receptor from the cannabinoid receptor family that in humans is encoded by the CNR2 gene.

This narrative review summarizes recent insights into the role of the CB2 receptor as potential therapeutic target in neuropathic pain and neurodegenerative conditions. The cannabinoid system continues to receive attention as a therapeutic target. ...

4-Bromo-2,5-dimethoxyphenethylamine (also known as Nexus, Bromo Mescaline, BDMPEA, Venus, and 2C-B) is a novel psychedelic substance of the phenethylamine class. It is perhaps the most well-known member of the 2C-x family, which are structurally related to the classical psychedelic mescaline.

In this review, we summarize our present knowledge of CB 2 receptor signaling, localization, and regulation. We discuss the availability of genetic tools (and their limitations) to study CB 2 receptors and also provide an update on preclinical data on CB 2 agonists in pain models.

Sep 4, 2024 · 2C-B is a Schedule I drug with no accepted medical drug use and a high potential for addiction. As a Class A drug, it’s illegal to buy, possess, and sell. Possession of 2C-B is punishable by up to 7 years in prison, a fine, or both. 2C …

2C-B is a hallucinogenic drug available as powder, pills or capsules and is almost always taken orally. Find out more about 2C-B dosage and effects.

Jul 26, 2022 · Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable, though as yet unrealised, therapeutic potential. Promising preclinical data supports the applicability of CB2 activation in autoimmune and inflammatory diseases, pain, neurodegeneration, and osteoporosis.

Mar 7, 2025 · Discover the effects and risks of 2C-B, a psychedelic drug part of the '2C' group, altering perception and emotions. Learn about its appearance and usage. Drug List

Introduction: Targeting CB2 cannabinoid receptor (CB2r) represents a promising approach for the treatment of central nervous system disorders. These receptors were identified in peripheral tissues, but also in neurons in the central nervous system.