Mdm2 has been identified as a p53 interacting protein that represses p53 transcriptional activity. Mdm2 achieves this repression by binding to and blocking the N-terminal trans-activation domain of p53. Mdm2 is a p53 responsive gene—that is, its transcription can be activated by p53.

Dec 25, 2024 · MDM2 (MDM2 Proto-Oncogene) is a Protein Coding gene. Diseases associated with MDM2 include Lessel-Kubisch Syndrome and Accelerated Tumor Formation . Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and Transport of the SLBP independent Mature mRNA .

Murine Double Minute Clone 2, located at 12q15, is an oncogene that codes for an oncoprotein of which the association with p53 was discovered 30 years ago. The most important function of MDM2 is to control p53 activity; it is in fact the best documented negative regulator of p53.

MDM2 is an oncogene that is frequently over-expressed in various human cancers, including sarcomas, gliomas, melanomas, and breast cancers. 1 The primary function of MDM2 is to inhibit the activity of the p53 tumor suppressor protein.

MDM2 is an oncoprotein that blocks p53 tumor suppressor-mediated transcriptional transactivation, escorts p53 from the cell nucleus to the cytoplasm, and polyubiquitylates p53. Polyubiquitylated p53 is rapidly degraded in the cytoplasm by the 26S proteasome.

Nov 25, 2020 · Histology and chromogenic in situ hybridization for MDM2 are shown. What is the most likely diagnosis?

Mouse double minute 2 (MDM2) is a critical negative regulator of the tumor suppressor p53, playing a key role in controlling its transcriptional activity, protein stability, and nuclear localization. MDM2 expression is up-regulated in numerous cancers, resulting in a loss of p53-dependent activities, such as apoptosis and cell-cycle arrest.

MDM2 promotes cancer cell survival through regulating the expression of HIF-1alpha and pVHL in retinoblastoma. EIF3B stabilizes PTGS2 expression by counteracting MDM2-mediated ubiquitination to promote the development and progression of malignant melanoma.

May 13, 2024 · Mousedouble minute 2 (MDM2) is one of the molecules activated by p53 and plays an important role in the regulation of p53. MDM2 is generally believed to function as a negative regulator of p53 by facilitating its ubiquitination and subsequent degradation.

Dec 1, 2003 · p53 transcriptionally activates many target genes, one of which is the mdm2 gene . p53 binds the mdm2 P2 promoter and transcriptionally up-regulates mdm2 expression. Because Mdm2 inhibits p53 activity, this forms a negative feedback loop that tightly regulates p53 function.