Each polyketide synthases is unique to each polyketide chain because they contain different combinations of domains that reduce the carbonyl group to a hydroxyl (via a ketoreductase), …

Polyketide synthases (PKSs) are a family of multi-domain enzymes or enzyme complexes that produce polyketides, a large class of secondary metabolites, in bacteria, fungi, plants, and a …

The different types of polyketide synthases catalyze the sequential condensation of two-carbon acetate units derived from a malonate thioester into a growing polyketide chain. Polyketide …

The meaning of POLYKETIDE is any of a large class of diverse compounds that are characterized by more than two carbonyl groups connected by single intervening carbon atoms, that are …

To facilitate the design of appropriate pathways to link and coordinate primary metabolism with polyketide biosynthesis, we first summarize the currently available precursor supply pathways …

polyketide-derived structures found in nature. Three major themes broadly describe the organization of polyketide synthases from diverse organisms, based in part on the well …

Polyketide natural products show great promise as medicinal agents. Typically the products of microbial secondary biosynthesis, polyketides are synthesized by an evolutionarily related but …

Mar 16, 2021 · A large family of polyoxygenated macrolide antibiotics, that contain 12-, 14-, or 16-membered lactone rings, share a polyketide biogenesis. For example, erythromycin B is a …

Jun 18, 2014 · Polyketide synthases (PKSs) are multi-domain enzyme complexes producing polyketides, a large class of secondary metabolites — in other words, natural products.

Jul 17, 2020 · Polyketide synthases are multi-domain enzymes that catalyse the construction of many bioactive natural products.