Oct 22, 2024 · Objectives To investigate the efficacy and safety of oral (PO) and subcutaneous (SC) lacosamide for refractory symptoms in the palliative setting. Methods We conducted a retrospective chart review of the use of lacosamide since it was introduced in our palliative care service 1½ years ago. All clinical notes, medication administration records and infusion monitoring documentation were ...

Clonidine is an alpha-2 adrenergic agonist licensed in the UK for hypertension, menopausal hot flushes and migraine prophylaxis. Randomised controlled trials (RCTs) confirm clonidine’s analgesic benefit in cancer pain (spinal), postoperative pain (intravenous (IV) spinal) and neuropathic pain (spinal and oral).1 2 IV clonidine achieves comparable analgesia to epidural clonidine, although ...

Introduction Caregivers play a major role in providing all the support and care in daily activities for their relatives with dementia. To fully describe the influence of dementia caregiving on family caregivers’ life, we conducted a systematic review including caregivers’ perceptions about the positive and negative aspects of caring and the expressed factors. Materials and methods We ...

2 Wang˜M, ea MJ Suoive aiaive Cae 224019 111362244984 Review as single-arm trials,6 cluster randomised trials7 and adaptive trials,8 have been developed. Single-arm trials refer to a design method in clin-ical research where only one experimental group

Chronic breathlessness is a disabling and distressing condition for which there is a growing evidence base for a range of interventions. Non-pharmacological interventions are the mainstay of management and should be optimised prior to use of opioid medication. Opioids are being implemented variably in practice for chronic breathlessness. This narrative review summarises the evidence defining ...

Introduction. Most patients with a deteriorating chronic illness have a reduced oral intake at the end of life. This may be due to illness or treatment-related symptoms or complications, such as dysphagia, nausea or vomiting, generalised weakness and, in the last days of life, to a decreased level of consciousness or a loss of desire to drink.1 2 …

Lack of knowledge about palliative care is one of the most common reasons for hindering the delivery of high-quality palliative care. Nurses play a major role in providing palliative care, and the degree of their mastery of this knowledge is crucial to whether they can effectively deliver the ideal palliative care. Therefore, it is necessary to understand the …

Introduction In 2021, we undertook a nation-wide online survey to explore public attitudes to death and dying in the UK (PADDUK).1 Due to the complexity and changing nature of public attitudes, we have been re-commissioned by Marie Curie to carry out an updated survey. Aim To explore current public attitudes to death, dying and bereavement in the UK and any changes in …

A wide range of adjuvant treatments have been studied to treat osteonecrosis. Photobiomodulation and photodynamic therapy are commonly used. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses systematic review was conducted to evaluate photobiomodulation and photodynamic therapy for the treatment of osteonecrosis related to the use of medications or related to ionising radiation.

Dec 26, 2024 · Implantable cardioverter defibrillators (ICDs) are implanted in increasing numbers of patients with the aim of treating ventricular arrhythmias in high-risk patients and reducing their risk of dying. Individuals are also living longer with these devices. As a result, a greater number of patients with an ICD will deteriorate either with worsening cardiac failure, another non …