The study of DNMT3A structure with substrates has long been hindered by the difficulty in producing a stable enzyme-substrate complex. "To overcome this challenge, we successfully developed a ...

Metabolism: Light shed on structure of huge enzyme complex Date: February 10, 2021 Source: Martin-Luther-Universität Halle-Wittenberg Summary: A new method has enabled the natural structure of ...

Figure 5: Standard view from the μPl substrate towards the active site of the μPl enzyme in complex with SAK (shown as a solid surface). The overall structure of the cleaved μPl substrate is ...

The study of DNMT3A structure with substrates has long been hindered by the difficulty in producing a stable enzyme-substrate complex. "To overcome this challenge, we successfully developed a ...