Researchers have successfully employed an algorithm to identify potential mutations which increase disease risk in the noncoding regions our DNA, which make up the vast majority of the human genome.

Most of the human genome consists of DNA that does not code for proteins. Annotating functional regions in the non-coding genome involves two complementary analysis techniques: comparative ...

Most of the genome is transcribed into RNA, but only a small proportion of RNAs are actually from the protein-coding regions of the genome. “Why are the non-coding regions transcribed at all? Their ...

such coding regions account for less than 2% of the human genome and, as the UCSD-led team points out, “attention is now shifting to the greater number of somatic mutations in noncoding regions.” ...

They found that non-coding constrained regions in the genome were rich in known regulatory elements and variants linked to human traits and diseases. The map could be helpful in improving our ...

Many sections of the non-coding region of the human genome play a key role in regulating gene activity. But the relationship between non-coding mutations and cancer risk has been a mystery.

Some genes are known to drive cancer, and astonishing new research shows why: Mutations in the noncoding regions become functional, altering the abundance of messenger RNA, or mRNA, and potentially ...

DNA molecules contain coding regions—the genes that code for proteins—and non-coding regions that are involved in the ...

However, disease-associated variants can also be found in these noncoding regions of the genome, which often control when proteins are made or "expressed." Since this "regulatory code" is not well ...

They discovered that a large fraction—33%—of somatic mutations in noncoding regions of 155 of the 166 tested cancer driver genes can change mRNA abundance. But Xiao's group didn't stop there.