Poly(ADP-ribose) polymerases (PARPs) are involved a number of cellular processes, including DNA repair, the regulation of transcription, apoptosis and necrosis. PARP activation initiates an energy ...

Growth inhibition, provoked by the combination of Me-Lex and PARP inhibitor, was associated with a marked down-regulation of c-myc, increased generation of single strand breaks and apoptosis.

PARP inhibitors treat late-stage prostate cancer that isn't responding to other treatments. Learn how they work, and when your doctor might prescribe one.

Patients with metastatic castration-sensitive prostate cancer (mCSPC), who have specific genetic mutations, were found to have improved radiographic progression-free survival (rPFS) by using PARP ...

Added Dr Salvatore Papa from the Institute of Hepatology London: "We discovered that too much PARP 14 effects other proteins in the body called kinases that control apoptosis.

PARP inhibitors are pharmaceutical drugs that can be used to treat many different forms of cancer, including ovarian and breast cancer.

This global PARP (poly ADP-ribose polymerase) inhibitors market 2019-2023 research report also analyzes other important trends and market drivers that will affect market growth over 2019-2023.

AZ and Merck were the first to grab an FDA approval for Lynparza, and, despite growing competition, the drug is set to remain top in the PARP space.

A study led by scientists at NYU Langone Health sheds light on how the major cancer gene BRCA2 determines which cancer cells can be killed by a class of precision cancer drugs called PARP inhibitors.

Programmed cell death serves as a critical defense mechanism during viral infection. The kinases RIPK1 and RIPK3, central regulators of programmed cell death pathways, undergo precise modulation ...

Apoptosis, as measured by c-PARP, was a prespecified exploratory biomarker with paired data available for 146 patients ( (47.6%; Fig 3 and Table 2). Other prespecified exploratory biomarkers are under ...

Introduction Substance P (SP) and its preferred receptor, the neurokinin-1 receptor (NK-1 R), are expressed in human tenocytes and this is particularly seen in the tenocytes in cases of tendinosis.